There were 17 patients who were used as the subject sin performing repair for bone defects caused by wisdom tooth issues through Italian scientists’ technique. Theirs is the first successful procedure in using implants of dental pulp stem or progenitor cells, DPCs dedicated for humans’ autologous oromaxillofacial bone regeneration according to their claims.
As per suggestion from the researchers, other reconstructive and orthopedic surgical areas can also make use of the approach which procedures and results were reported in a paper through European Cells and Materials having the title “Human Mandible Bone Defect Repair by Grafting of Dental Pulp Stem /Progenitor Cells and Collagen Sponge Biocomplexes.”
Extraction and expansion of DPCs from the maxillary third molars or wisdom teeth was involved in the process of human trial done by Professor Gianpaolo Papaccio, Ph.D. and team at the Second University of Naples. The procedure was done on 17 patients that need wisdom tooth extraction. A collagen sponge scaffold is then used to have the cells seeded and the injury site after having the tooth removed will then be filled with the resulting biocomplex.
While it has been depicted through historical observations of the injury site’s complete bone regeneration, treated patient’s alveolar bone showed optimal vertical repair along with its periodontal tissue’s complete restoration back to the second molars after autologous DPC grafting as seen through an X-ray evaluation done three months after the procedure.
“Stem cells represent an easy and natural alternative to repair/regenerate damaged tissues,” according to the Naples team concluding that the autologous DPC technique is the bone tissue engineering’s new tool. Adding, “This is essential, especially when bone loss subsequent to degenerative or traumatic diseases cannot be amended through conventional therapies. The procedure is efficient, exhibits low morbidity of the collection site, and is free from diseases incurred by transmission of pathogens. The regeneration process is fast and efficient.”
Collecting, assessing and cryogenically storing of living tooth cells coming from deciduous baby teeth are the functions of BioEden, a Dental biobanking company that have the achievement welcomed as they claimed the success “yields a vast number of medical possibilities for dental stem cells and for those people who store them for future use.”
BioEden owns global patent for the extraction, cryopreservation and storage of dental stem cells for medical purposes, was founded in Austin, TX has laboratories in the U.K that serve Europe as well as Thailand (serving the South East Asia). However, the Middle East, India, Russia and Australia were spotted for their planned bases.